Endocrine Abstracts

Introduction:Adrenocorticotropic hormone (ACTH) deficiency can occur either due to decreased or absent production of the hormone by the pituitary gland. A decline in the production of ACTH can result in adrenal insufficiency. The exact etiology of ACTH deficiency is unknown. A defect in the hypothalamus or pituitary gland may be the cause. This can also be congenital involving mutations of the TBX19 gene (also referred to as TPIT) on the long arm of chro...

Maternally inherited diabetes and deafness (MIDD) is rare subtype and monogenic form of adult onset diabetes caused from point mutation at position 3243 of mitochondrial DNA. The name indicates the main features of disease including diabetes and sensorineural hearing loss. About one percent of people with diabetes can have MIDD but the diagnosis can be challenging and needs high clinical suspicion on basis of family history, clinical features of diabetes, deafness and unusual ...